Rick Silverman

Curriculum Vitae

Address:
Department of Chemistry
Northwestern University
2145 Sheridan Road
Evanston, IL 60208-3113
Telephone: (847)491-5653
Fax: (847)491-7713
Email: Agman@chem.northwestern.edu

Date of Birth:
May 12, 1946
Philadelphia, PA

Marital Status:
Married, 3 children

Positions Held:

     

  • 9/1/15-present Patrick G. Ryan/Aon Professor
  • 9/1/04-8/31/15 John Evans Professor of Chemistry, Northwestern University
  • 9/1/01-8/31/04 Charles Deering McCormick Professor of Teaching Excellence, Northwestern University
  • 9/90-present Professor of Chemistry and Professor of Biochemistry, Molecular Biology, and Cell Biology; Member of the Institute for Neuroscience, Member of the Drug Discovery Program, Member of the Lurie Cancer Center, Northwestern University
  • 1/1/96-12/31/97 Arthur Andersen Professor of Chemistry and of Biochemistry, Molecular Biology, and Cell Biology; Member of the Institute for Neuroscience, Northwestern University
  • 9/86 - 9/90 Professor of Chemistry and Professor of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University
  • 9/84 - 9/86 Associate Professor of Chemistry and Associate Professor of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University
  • 9/82 - 9/84 Associate Professor of Chemistry, Northwestern University
  • 9/76 - 9/82 Assistant Professor of Chemistry, Northwestern University

Education:

  • 9/68- 1/69  Harvard University (Advisor: Professor David H. Dolphin, Department of Chemistry)
  • 1/71 - 6/74 Ph.D. in organic chemistry. Thesis: Model Studies for Coenzyme B12-Dependent Enzyme-Catalyzed Rearrangements.
  • 4/64 - 3/68 Pennsylvania State University B.S. in chemistry

Postdoctoral Experience:

  • 7/74 - 9/76 Brandeis University (Advisor: Professor Robert H. Abeles, Graduate Department of Biochemistry) Specific Enzyme Inactivation

Military Service:

  • 1/69 - 1/71 United States Army Physical Sciences Assistant, Walter Reed Army Institute of Research, Washington, D.C., Honorable discharge, 1/71

Other Research Experience

  • 5/69 - 1/71 Walter Reed Army Institute of Research
    Synthesis of potential anti-radiation agents
  • 4/68 - 9/68 Rohm and Haas Company
    Synthesis of elastomeric fibers
  • 4/67 - 1/68 Pennsylvania State University
    B.S. Thesis: Some Chemistry of Tungsten Carbony Carbene Complexes
  • 6/66 - 9/66 Atlantic-Richfield
    Fuel cell research

Professional Memberships:

  • American Chemical Society
  • American Association for the Advancement of Science
  • American Society for Biochemistry and Molecular Biology

Research Interests:

  • Medicinal and bioorganic chemistry: mechanism of drug action;
    design of medicinal agents; specific enzyme inactivation;
    enzyme mechanisms; enzyme models

 

Awards

Pennsylvania State University

  • Magna Cum Laude
  • National Chemistry Honor Society (Phi Lambda Upsilon)
  • National Science Honor Society (Phi Kappa Phi)
  • National Freshmen Scholastic Honor Society (Phi Eta Sigma)
  • J. Paul Smith Memorial Scholarship, 1966-1968
  • Alumni Fellow Award, 2008

United States Army

  • U.S. Army Commendation Medal for meritorious service 1971

Harvard University

  • NIH Predoctoral Training Grant 1971-1974
  • Outstanding Teaching Fellow Fall, 1973 (excellence in teaching organic chemistry)

Brandeis University

  • NIH Postdoctoral Fellowship 7/74 - 9/76 (declined an American Cancer Society Postdoctoral Fellowship)

Northwestern University

  • Du Pont Young Faculty Fellow 1976
  • Alfred P. Sloan Research Fellow 1981-1985
  • NIH Research Career Development Awardee 1982-1987
  • Fellow of the American Institute of Chemists 1985
  • Fellow of the American Association for the Advancement of Science 1990
  • Northwestern University Faculty Honor Roll (based on undergraduate students' 1977-1982, evaluations of teaching) (top 3%) 1978-1979, 1986, 1997, 2008
  • E. LeRoy Hall Award for Teaching Excellence 1999
  • Northwestern University Alumni Teaching Award 2000
  • Arthur C. Cope Senior Scholar Award of the ACS 2003
  • Alumni Fellow Award, Pennsylvania State University 2008
  • Perkin Medal, Society of Chemical Industry 2009
  • Medicinal Chemistry Hall of Fame of the ACS 2009
  • Alumni Hall of Fame, Central High School of Philadelphia 2011
  • E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances of the ACS 2011
  • Fellow of the American Chemical Society 2011
  • Sato Memorial International Award of the Pharmaceutical Society of Japan 2012
  • Roland T. Lakey Award from Wayne State University 2013
  • Bristol-Myers Squibb-Edward E. Smissman Award of the American Chemical Society 2013
  • Centenary Prize of the Royal Society of Chemistry 2013
  • Fellow of the Royal Society of Chemistry (UK) 2013
  • Medicinal Chemistry Prize of the Israel Chemical Society 2014
  • Northwestern University Trustee Medal for Faculty Innovation and Entrepreneurship 2014
  • iCON Innovator Award of the iBIO Institute 2014
  • Fellow, American Academy of Arts & Science 2014
  • Fellow, National Academy of Inventors 2014

 

Honors and Other Professional Activities

  • Pharmaceutical Inventions
    • Inventor of LyricaTM (pregabalin), marketed worldwide for the treatment of epilepsy, neuropathic pain, fibromyalgia, and (in Europe) for generalized anxiety disorder.
  • Editorial Boards
    • Journal of Medicinal Chemistry 1995-2000
    • Archiv der Pharmazie- Pharmaceutical and Medicinal Chemistry 1995-2014
    • Archives of Biochemistry and Biophysics 1993-2003
    • Journal of Enzyme Inhibition and Medicinal Chemistry 1988-2012
    • InScight 1999-present
    • Guest Editor for a Symposium-in-Print in Bioorganic & Medicinal Chemistry 1996
    • Editorial Board of Reviewers for the textbook Biochemistry, Abeles, R. H.; Frey, P. A.; Jencks, W. P.; Jones and Bartlett: Boston 1992
    • Bioorganic & Medicinal Chemistry 2003-present
    • Bioorganic & Medicinal Chemistry Letters 2003-present
    • Letters in Drug Design & Discovery 2003-2011
    • Current Enzyme Inhibition 2004-present
    • Section Editor for The Practice of Medicinal Chemistry, 3rd edition, Wermuth, C. G., editor 2007-2008
  • Scientific Advisory Boards
    • Influx, Inc. 1998-present
    • Protez Pharmaceuticals, Inc. 2004-
    • SynChem, Inc. 2004-
    • University of Illinois, Chicago, NIH Anthrax Project 2006
    • University of Illinois, Chicago, NIH SARS Project 2007
    • Cambria Pharmaceuticals LLC 2007-
  • International Advisory Committees
    • 10th International Amine Oxidase Workshop 8/2002
      (Istanbul, Turkey)
    • XVIIIth International Symposium on Medicinal Chemistry (Copenhagen, Denmark) 9/2004
  • National Offices Held
    • Elected Office: Program Chair, Division of Biological Chemistry, ACS 2001
    • Member, Long-Range Planning Committee for the Division of Medicinal Chemistry, ACS 1999-2002
    • Elected Office: Treasurer, Division of Biological Chemistry, American Chemical Society 1993-1996
    • Elected Office: Nominating Committee, Division of Biological Chemistry of the American Chemical Society 1990
    • Elected Office: Program Chair, Division of Biological Chemistry, ACS 2001
    • Member, Canvassing Committee for the American Chemical Society Alfred Burger Award in Medicinal Chemistry 1982-1987
    • Chairman 1986-1987
    • Member, American Chemical Society Organic Chemistry Examination Committee 1986
    • Member, Long-Range Planning Committee for the Division of Medicinal Chemistry 1999-2002
  • NIH Advisory Panels
    • Permanent member, Bioorganic and Natural Products Chemistry Study Section 1987-1991
    • NIH Ad hoc Reviewer for Moleular Structure and Function of Enzymes Study Section, June 2007
    • NIH Ad hoc Reviewer for Center for Scientific Review Special Emphasis Panel November 2005
    • NIH Ad hoc Reviewer for Macromolecular Structure and Function Study Section March 2005
    • National INstitutes of General Medical Sciences Advisory Council September 2002
    • NIH Ad hoc Reviewer for Bioorganic & Medicinal Chemistry Study Section Oct., 2001
    • NIH Ad hoc Reviewer for Chemistry and Related Sciences Study Section Nov., 1996
    • NIH Ad hoc Reviewer for Medicinal Chemistry A Study Section (AREA proposals) Nov., 1993
    • NIH Special Reviewer for Bio-Organic and Natural Products Chemistry Study Section Feb., 1987
    • NIH Special Study Sections 12/83; 7/85
    • NIH Program Project Site Visits and Special Pharmacological Sciences Review Committees:
      • University of Washington Feb., 1983
      • University of Kansas June, 1981
  • Conference Organizer/Chair
    • Co-Chair, Gordon Research Conference on Enzymes, Coenzymes, and Metabolic Pathways 1994
    • Co-Vice Chair, Gordon Research Conference on Enzymes, Coenzymes, and Metabolic Pathways 1993
    • Organizer , 27th ACS Great Lakes Regional Meeting
    • Organizer of the entire program for the Division of Biological
    • Chemistry of the ACS Nat'l Meeting 2001
    • Organizer and Chair, Symposium on Dual-Acting Drugs, ACS Nat'l Meeting (DC) 2000
    • XVIII International Symposium on Medicinal Chemistry (Copenhagen, Denmark) 2004
    • Session Chair, 5th Chemical Congress of North America Symposium on NO Synthase Inhibitors 1997
    • Program Committee, National Medicinal Chemistry Symposium 1996
    • Organizer and Chairman of the 2nd, 14th and 26th Annual Midwest Enzyme Chemistry Conference, Chicago 1982, 1994, 2006, 2010
    • Organizer and Chairman of the Northwestern UniversityDepartment of Chemistry Byron Riegel Lecture Series (Mechanism of Action and Design of Drugs) 1980
  • Expert Analyst for CHEMTRACTS 1988-1994
  • Special Lectureships
    • Plenary Lecturer, 4th Society of Chemical Industry-Royal Society of Chemistry, Medicinal Chemistry Symposium (Cambridge, England) Sept., 1987
    • Plenary Lecturer, 14th Scientific Sessions of the Rhone-Poulenc Society (Lyon, France) Nov., 1991
    • Pew Lecturer, Wheaton College (Wheaton, IL) Apr., 1992
    • Plenary Lecturer, 20th Anniversary Marion Merrell Dow Research Institute (Strasbourg, France) May, 1993
    • Peters Lecturer, Virginia Polytechnic Institute and State University (Blacksburg, VA) Oct., 1993
    • Burkett Lecturer, DePauw University (Greencastle, IN) Apr., 1994
    • Teaching faculty at the Residential School on Medicinal Chemistry, Drew University (Madison, NJ) 1995-present
    • Plenary Lecturer, VII Meeting on Heterocyclic Structures in Medicinal Chemistry (Mondello, Sicily) May, 1996
    • Plenary Lecturer, University of Pennsylvania enzyme Symposium III (Philadelphia, PA) 1997
    • Plenary Lecturer, 40th Annual MIKI Meeting (Chicago, IL) 2002
    • Plenary Lecturer, Norwegian Organic Chemistry Winter Meeting (Roros, Norway) 2004
    • Frontier Science Lecturer, Wayne State University, Department of Chemistry (Detroit, MI) 2004
    • Plenary Lecturer, Science at the Interface of Chemistry and Biology, University of Notre Dame, Department of Chemistry and Biochemistry (South Bend, IN) 2004
    • Plenary Lecturer, International Conference on Chemistry Biology Interface: Synergistic New Frontiers (Dr. B.R. Ambedkar Center for Biomedical Research, New Delhi, India) 2004
    • Plenary Lecturer, IVth National Meeting on Medicinal Chemistry, (Caracas, Venezuela) 2007
    • Kilpatrick Lecturer, Illinois Institute of Technology (Chicago, IL) 2008
    • Plenary Lecturer, Royal Australian Chemical Institute, Division of Biomolecular Chemistry (Couran Cove, QLD, Australia) 2008
    • Ira Kukin Chemistry Lecturer, Yeshiva University (New York, NY) 2009
    • Plenary Lecturer, Canadian Society for Chemistry (Toronto, Ontario, Canada) 2010
    • Tyler Lecturer, Purdue University (West Lafayette, IN) 2010
    • Bernard Belleau Lecturer, McGill University (Montreal, Quebec, Canada) 2011
    • Len Owen Lecturer, Imperial College (London, UK) 2013
    • Jack Fox Memorial Lecturer, Memorial Sloan-Kettering Cancer Center (New York, NY) 2014

    • Kenneth L. Rinehart, Jr. Lecturer in Chemical Biology, University of Illinois at Urbana-Champaign 2014

    • Nakamoto Lecturer, Marquette University 2015
    • Hovey Lecturer, Wabash College 2015
  • Consultantships
    • Procter and Gamble 1984
    • Abbott Laboratories 1987
    • Searle/Monsanto 1988-1990
    • Leydig, Voit & Mayer Law Offices 1992-present
    • DowElanco 1993-1995
    • Searle & Co. 1995
    • Rohm & Haas 1995
    • Affymax 1995
    • Kinetek Pharmaceuticals 1999-
    • Guilford Pharmaceuticals (Baltimore MD) 2001
    • ActivX Biosciences (La Jolla, CA) 2001
    • Cytoclonal Pharmaceutics (now eXegenics) (Dallas, TX) 2001
    • Hawaii Biotech, Inc. (Aiea, HI) 2003-2006
    • SynChem, Inc. (Des Plaines, IL) 2003-
  • Short Courses Given
    • "The Organic Chemistry of Enzyme-Catalyzed Reactions"
      • E.I. Du Pont de Nemours 9/91
      • Dow Chemical Company 9/91
      • American Chemical Society National Meeting (San Francisco) 4/92
      • Indianapolis Section of the American Chemical Society 12/92
      • American Chemical Society National Meeting (Chicago) 8/93
      • Procter & Gamble Pharmaceuticals 11/94
      • BioChem Pharma, Inc. 4/99
    • "The Organic Chemistry of Drug Design and Drug Action"
      • American Chemical Society National Meeting (Anaheim) 4/95
      • American Chemical Society National Meeting (Chicago) 8/95
      • Western Regional American Chemical Society Meeting (San Diego) 10/95
      • American Chemical Society (Somerset, NJ) 11/95
      • American Chemical Society (New Orleans, LA) 3/96
      • American Chemical Society (Orlando, FL) 8/96
      • American Chemical Society (Boston, MA) 12/96
      • American Chemical Society (San Francisco, CA) 4/97
      • American Chemical Society (Philadelphia, PA) 4/97
      • Bayer Pharmaceuticals (West Haven, CT) 5/97
      • American Chemical Society (Las Vegas, NV) 9/97
      • American Chemical Society (Dallas, TX) 4/98
      • Pharmaceutical Ingredients Society (Philadelphia, PA) 5/98
      • St. Louis Section of ACS 5/98
      • American Chemical Society (Boston, MA) 8/98
      • PITTCON (Orlando, FL) 3/99
      • American Chemical Society (Anaheim, CA) 3/99
      • Eli Lilly and Co. (Indianapolis, IN) 6/99
      • Drug Discovery Technology '99 (Boston, MA) 8/99
      • American Chemical Society (New Orleans, LA) 8/99
      • WorldPharm '99 (Philadelphia, PA) 10/99
      • San Francisco (c/o ACS) 12/99
      • Hoffmann-La Roche (Nutley, NJ) 12/99
      • Pittcon (New Orleans, LA) 3/00
      • Bayer (Kyoto, Japan) 3/00
      • AstraZeneca (St. Laurent, Quebec, Canada) 6/00
      • Sphinx Pharmaceuticals (Research Triangle Park, NC) 6/00
      • Drug Discovery Technology 2000 (Boston, MA) 8/00
      • American Chemical Society (Washington, DC) 8/00
      • Bristol-Myers Squibb (Wallingford, CT) 9/00
      • American Chemical Society (San Diego, CA) 4/01
      • Bristol-Myers Squibb (Princeton, NJ) 7/01
      • Drug Discovery Technology 2000 (Boston, MA) 8/01
      • American Chemical Society (Chicago, IL) 8/01
      • American Chemical Society (San Francisco, CA) 12/01
      • New York Police Department (Jamaica, NY) 3/02
      • American Chemical Society (Orlando, FL) 4/02
      • American Chemical Society (Boston, MA) 8/02
      • American Chemical Society (Boston, MA) 11/02
      • American Chemical Society (San Francisco, CA) 12/02
      • PPD Discovery (Morrisville, NC) 12/02
      • American Chemical Society (New Orleans, LA) 3/03
      • Drug Discovery Technology 2003 (Boston, MA) 8/03
      • American Chemical Society (New York, NY) 9/03
      • Bristol-Myers Squibb (Wallingford, CT) 6/03
      • American Chemical Society (San Francisco, CA) 12/03
      • American Chemical Society (Anaheim, CA) 3/04
      • Gilead Pharmaceuticals (Mountain View, CA) 4/04
      • Pfizer Pharmaceuticals (San Diego, CA) 4/04
      • Procter & Gamble (Cincinnati, OH) 5/04
      • Bristol-Myers Squibb (Princeton, NJ) 6/04
      • American Chemical Society (Philadelphia, PA) 8/04
      • American Chemical Society (San Diego, CA) 3/05
      • American Chemical Society (Washington, DC) 8/05
      • Encysive Pharmaceuticals (Houston, TX) 11/05
      • American Chemical Society (San Francisco, A) 9/06
      • IVth National Meeting on Medicinal Chemistry (Caracas, Venezuela) 6/07
  • Inclusion in International Biographical Texts
    • Who's Who in Frontiers of Science and Technology 1984, 1985
    • International Who's Who of Contemporary Achievement 1985
    • Who's Who in the Midwest 1986-1988, 1991
    • Personalities of America 1986
    • Who's Who in Society 1986, 1988
    • Men of Achievement 1986
    • Who's Who of Emerging Leaders in America 1987
    • Who's Who in America 1988-2010
    • Who's Who in American Education 1994-2008
    • Who's Who in Science and Engineering 1996-2008
    • Who's Who Among American's Teachers 2000
  • Advisory Board Member, Illinois Mathematics and Science Academy 1988
  • Honorary Member of the Golden Key National Honor Society 1994
  • Selection Committee for the Division of Medicinal Chemistry Award 1998
  • Ad hoc reviewer for the following journals: Science, J. Am. Chem. Soc., Biochemistry, J. Biol. Chem., J. Org. Chem., J. Med. Chem., Arch. Biochem. Biophys., J. Neurochem., Mol. Toxicol., Can. J. Chem., Biochim. Biophys. Acta, Biochem. Internat., Bioorg. Chem., Biochem. Pharmacol., Chem. Res., Toxicol., Eur. J. Med. Chem., Mol. Pharmacol., Bioorg. Med. Chem. Lett., Tetrahedron, Int. J. Peptide Protein Res., Bioorg. Med. Chem., Angew. Chem. Int. Ed. Engl., Tetrahedron Lett., Synlett, Int. J. Biochem. Cell Biol., Med. Chem. Res., J. Heterocycl. Chem.
  • Ad hoc reviewer for the following books: American Chemical Society, Division of Medicinal Chemistry and Division of Agrochemicals, Encyclopedia of Chemical Technology
  • Ad hoc reviewer for the following funding agencies: National Science Foundation, Office of Naval Research, Petroleum Research Fund, Research Corporation, National Research Council (Canada), Human Frontier Science Program, Amherst College Research Fund, US Department of Agriculture, North Carolina Biotechnology Center, NSERC, The Wellcome Trust

 

Books

Silverman, R.B. Mechanism-Based Enzyme Inactivation: Chemistry and Enzymology, Vols. I and II; CRC Press: Boca Raton, FL; 1988.

2a. Silverman, R.B. The Organic Chemistry of Drug Design and Drug Action; Academic Press: San Diego; 1992.

2b. Silverman, R. B. Medizinische Chemie für Organiker, Biochemiker und Pharmazeutische Chemiker, VCH: Weinheim; 1995 (German Translation by Joachim K. Seydel of The Organic Chemistry of Drug Design and Drug Action).

3. Silverman, R. B. The Organic Chemistry of Enzyme-Catalyzed Reactions, Academic Press: San Diego; 2000; revised, 2002.

4. Silverman, R.B. The Organic Chemistry of Drug Design and Drug Action; 2nd Edition; Elsevier/Academic Press: San Diego; 2004.

5. Silverman, R.B.; Holladay, M. W. The Organic Chemistry of Drug Design and Drug Action; 3rd Edition; Elsevier/Academic Press: San Diego; 2014.

 

 

Patents

  • Flint, D.H.; Silverman, R.B. U.S. Pat. 4,528,028 (July 9, 1985) "Use of Certain Halogen-Containing Amino-Acid Compounds for Controlling the Growth of Unwanted Plants."
  • Estreicher, H.; Flint, D.H.; Silverman, R.B. U.S. Pat. 4,582,529 (April 15, 1986) "Use of Certain Acetylene-Substituted Amino-Acid Compounds for Controlling the Growth of Unwanted Plants."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,563,175 (October 8, 1996) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,599,973 (February 4, 1997) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,608,090 (March 4, 1997) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Australian Pat. 677008 (April 10, 1997) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. New Zealand Pat. 253459 (July 9, 1997) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,684,189 (November 4, 1997) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,710,304 (January 20, 1998) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Russian Pat. 2,103,259 (January 27, 1998) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,847,151 (December 8, 1998) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Russian Pat. 2140901 (Nov. 10, 1999) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Czech Republic Pat. 286106 (Jan. 12, 2000) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,028,214 (February 22, 2000) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,117,906 (September 12, 2000) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. U.S. Patent 6,140,366 (Oct. 31, 2000) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R. U. S. Pat. 6,197,819 (March 6, 2001) "Gamma Amino Butyric Acid Analogs and Optical Isomers."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,255,345 B1 (July 3, 2001) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,262,120 B1 (July 17, 2001) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Huang, H.; Zhang, H. Q. U.S. Pat. 6,274,557 B1 (Aug. 14, 2001) "Inhibition of Nitric Oxide Synthase by Amino Acids and Dipeptides"
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. U.S. Pat. 6,291,526 B1 (Sept. 18, 2001) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Danish Pat. DK/EP 0641330 (Dec. 3, 2001) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. Singapore Pat. 9608718-4 (Jan. 4, 2002) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. U.S. Pat. 6,342,529 B1 (Jan. 29, 2002) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,359,169 B1 (Mar. 19, 2002) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. Austrian Pat. AT E 207052 T1 (Mar. 25, 2002) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. Hong Kong Pat. HK1011022 (Mar. 28, 2002) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. German Pat. 69330949 T2 (Apr. 4, 2002) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Greek Pat. 3037855 (Apr. 29, 2002) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,414,024 B1 (July 2, 2002) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Lee Y. U.S. Pat. 6,416,861 (July 9, 2002) "Organosilicon Compounds and Uses Thereof."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,525,096 B1 (Feb. 25, 2003) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. Slovakian Patent 283,281 (March 3, 2003) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A.; Silverman, R. B.; Andruszkiewicz, R. Mexican Patent 215885 (August 18, 2003) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Pan, Y. U. S. Patent 6,794,413 (September 21, 2004) "Compounds and Related Methods for Inhibition of γ-Aminobutyric Acid Aminotransferase."
  • Silverman, R. B.; Hah, J.-M.; Gómez Vidal, J. A. U. S. Patent 6,803,486 (Oct. 12, 2004) "Selective Neuronal Nitric Oxide Synthase Inhibitors."
  • Silverman, R. B.; Yuen, P.-W.; Franklin, L. C.; Andruszkiewicz, R.; Sobieray, D. M.; Schwindt, M. A. Canadian Pat. 2,134,674 (Dec. 21, 2004) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Pan, Y. U. S. Patent 7,381,748 (June 3, 2008). "Compounds and Related Methods for Inhibition of Gamma-Aminobutyric Acid Aminotransferase."
  • Silverman, R. B.; Ji, H. U.S. Patent 7,470,790 (Dec. 30, 2008). "Heteroaromatic Selective Inhibitors of Neuronal Nitric Oxide Synthase"
  • Silverman, R. B.; Hah, J. M.; Gomez Vidal, J. A.; Erdal, E. U.S. Patent 7,470,815 (Dec. 30, 2008). "Selective Neuronal Nitric Oxide Synthase Inhibitors"
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. Japan Pat. 4,297,814 (April 24, 2009) "GABA and L-Glutamic Acid Analogs for Antiseizure Treatment."
  • Silverman, R. B.; Liu, S.; Gu, W.; Adrian, T.; Soff, G. U.S. Patent 7,709,443 (May 4, 2010). "Cyclic Peptide Antitumor Agents."
  • Silverman, R. B.; Ji, H.; Lawton, G. R. U.S. Patent 7,994,326 (August 9, 2011). Potent and Highly Selective Heteroaromatic Inhibitors of Neuronal Nitric Oxide Synthase.
  • Silverman, R. B.; Liu, S.; Gu, W.; Adrian, T. E.; Soff, G. A. U.S. Patent 8,058,244 B2 (Nov. 15, 2011). "Cyclic Peptide Antitumor Agents."
  • Silverman, R. B.; Ji, H. U.S. Patent 8,158,658 B2 (April 17, 2012). Heteroaromatic selective inhibitors of neuronal nitric oxide synthase
  • Ilan, Y.; Zigmond, E.; Silverman, R. B.; Lu, H. U.S. Patent 8,211,865 B2 (July 3, 2012). Inhibition of ornithine aminotransferase for the treatment of proliferative disorders.
  • Silverman, R. B.; Xue, F. U.S. Patent 8,278,084 B2 (October 2, 2012). Aminopyridine diner compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
  • Silverman, R. B.; Xue, F. U.S. Patent 8,299,100 B2 (October 30, 2012). Potent and selective neuronal nitric oxide synthase inhibitors with improved membrane permeability
  • Silverman, R. B.; Xue, F. U.S. Patent 8,389,731 B2 (March 5, 2013). Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase
  • Silverman, R. B.; Liu, S.; Gu, W.; Adrian, T. E.; Soff, G. A. U.S. Patent 8,492,345 B2 (July 23, 2013). Cyclic peptide antitumor agents
  • Silverman, R. B.; Ji, H.; Huang, H. U.S. Patent 8,557,552 B2 (October 15, 2013). Selective neuronal nitric oxide synthase inhibitors
  • Silverman, R. B.; Kraus, J. M. U.S. Patent 8,618,143 B1 (December 31, 2013). Selective neuronal nitric oxide synthase inhibitors with azole substituents
  • Meyskens, F. L., Jr.; Silverman, R. B.; Yang, S.; Ji, H.; Xue, F.; Poulos, T. P. U.S. Patent 8,642,282 B2 (February 4, 2014). Inhibitors of nitric oxide synthase for treatment of melanoma
  • Ilan, Y.; Zigmond, E.; Silverman, R. B.; Lu, H. U.S. Patent 8,686,041 B2 (April 1, 2014). Inhibition of ornithine aminotransferase for the treatment of proliferative disorders
  • Silverman, R. B.; Xue, F. U.S. Patent 8,697,879 B2 (April 15, 2014). Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors

  • Silverman, R. B.; Kudoh, T. U.S. Patent 8,710,032 B2 (April 29, 2014). Inhibitors of the mevalonate pathway of Streptococcus pneumonia
  • Kirsch D. R.; Benmohamed, R.; Arvanites, A. C.; Morimoto, R. I.; Zhang, W.; Silverman, R. B. U.S. Patent 8,722,939 B2 (May 13, 2014). Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis
  • Silverman, R. B.; Huang, H.; Jing, Q. U.S. Patent 8,735,606 B2 (May 27, 2014). Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors
  • Silverman, R. B.; Xue, F. U.S. Patent 8,829,187 B1 (September 9, 2014). Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase
  • Silverman, R. B.; Xue, F. U.S. Patent 8,927,730 B2 (January 6, 2015). Intramolecular hydrogen-bonded nitric oxide synthase inhibitors
  • Silverman, R. B.; Xue, F.; Huang, H. U.S. Patent 8,932,842 B2 (January 13, 2015). Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
  • Silverman, R. B.; Dewey, S. L.; Miller, S. U.S. Patent 8,969,413 B2 (March 3, 2015). Methods of using (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid
  • Silverman, R. B.; Meyskens, F. L.; Yang, S.; Ji, H.; Xue, F.; Poulos, T. L. U.S. Patent 9,090,589 B2 (July 28, 2015). Specific nNOS inhibitors for the therapy and prevention of human melanoma
  • Silverman, R. B.; Jing, Q. U.S. Patent 9,120,750 B2 (September 1, 2015). 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
  • Silverman, R. B.; Zhang, Y. U.S. Patent 9,145,424 B2 (September 29, 2015). Treatment of amyotrophic lateral sclerosis
  • Silverman, R. B.; Watanabe, M.; Kang, S. S.; Leyh, T. S. U.S. Patent 9,150,534 B2 (Oct. 6, 2015). Prodrugs of fluorinated mevalonates to inhibit the mevalonate pathway of Streptococcus pneumonia
  • Kirsch, D.; Benmohamed, R.; Arvanites, A. C.; Morimoto, R. I.; Zhang, W.; Silverman, R. B. U.S. Patent 9,162,968 B2 (Oct. 20, 2015). Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis